MPMI (drug)

MPMI
Clinical data
Other names3-(N-Methylpyrrolidin-3-ylmethyl)indole; N-Methyl-α,N-trimethylenetryptamine; α,N-Trimethylene-N-methyltryptamine
Drug classSerotonin receptor agonist
Identifiers
IUPAC name
  • 3-[(1-methylpyrrolidin-2-yl)methyl]-1H-indole
CAS Number
PubChem CID
ChemSpider
Chemical and physical data
FormulaC14H18N2
Molar mass214.312 g·mol−1
3D model (JSmol)
SMILES
  • CN1CCCC1CC2=CNC3=CC=CC=C32
InChI
  • InChI=1S/C14H18N2/c1-16-8-4-5-12(16)9-11-10-15-14-7-3-2-6-13(11)14/h2-3,6-7,10,12,15H,4-5,8-9H2,1H3
  • Key:HCTCDEAMCNSARD-UHFFFAOYSA-N

MPMI, also known as 3-(N-methylpyrrolidin-3-ylmethyl)indole or as N-methyl-α,N-trimethylenetryptamine, is a pyrrolidinylmethylindole and cyclized tryptamine which acts as a serotonin receptor agonist. It has been studied as an analogue and trace impurity of the antimigraine drug eletriptan but is otherwise little known.[1][2]

Chemistry

Analogues

Analogues of MPMI include 4-HO-MPMI, 5-MeO-MPMI, 5F-MPMI, eletriptan, CP-122288, CP-135807, 10,11-secoergoline (α,N-Pip-T), pyr-T, SN-22, and α,N,N-trimethyltryptamine, among others.

See also

References

  1. ↑ FI 105812, Wythes MJ, Macor JE, "Menetelmä terapeuttisesti käyttökelpoisten indolijohdannaisten valmistamiseksi", issued 14 April 1993, assigned to Pfizer, Inc.
  2. ↑ US 5607951, Macor JE, Wythes MJ, "Indole derivatives", issued 4 March 1997, assigned to Pfizer, Inc.
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