Bay R 1531

Bay R 1531
Clinical data
Other namesLY-197206; LY197206
Drug classSerotonin 5-HT1A receptor agonist; Simplified/partial LSD analogue
Identifiers
IUPAC name
  • 1,3,4,5-tetrahydro-6-methoxy-N,N-dipropyl-benz[cd]indol-4-amine
CAS Number
PubChem CID
PubChem SID
ChemSpider
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC18H26N2O
Molar mass286.419 g·mol−1
3D model (JSmol)
SMILES
  • COc2ccc1[nH]cc3CC(Cc2c13)N(CCC)CCC
InChI
  • InChI=1S/C18H26N2O/c1-4-8-20(9-5-2)14-10-13-12-19-16-6-7-17(21-3)15(11-14)18(13)16/h6-7,12,14,19H,4-5,8-11H2,1-3H3
  • Key:BMZWFSGTPJUKJR-UHFFFAOYSA-N

Bay R 1531, also known as LY-197206, is a tricyclic tryptamine derivative. It acts as a selective serotonin 5-HT1A receptor agonist. It was investigated unsuccessfully for the treatment of stroke but continues to be used in scientific research.[1][2][3][4] It shows very high affinity for the serotonin 5-HT1A receptor (Ki = 1.3 nM).[5][6]

See also

References

  1. ↑ Bielenberg GW, Burkhardt M (December 1990). "5-hydroxytryptamine1A agonists. A new therapeutic principle for stroke treatment". Stroke. 21 (12 Suppl): IV161-3. PMID 2148035.
  2. ↑ Critchley MA, Njung'e K, Handley SL (1992). "Actions and some interactions of 5-HT1A ligands in the elevated X-maze and effects of dorsal raphe lesions". Psychopharmacology. 106 (4): 484–90. doi:10.1007/bf02244819. PMID 1533721. S2CID 8404850.
  3. ↑ Canto de Souza A, Nunes de Souza RL, Péla IR, Graeff FG (March 1997). "High intensity social conflict in the Swiss albino mouse induces analgesia modulated by 5-HT1A receptors". Pharmacology, Biochemistry, and Behavior. 56 (3): 481–6. doi:10.1016/s0091-3057(96)00246-8. PMID 9077586. S2CID 20078255.
  4. ↑ Canto-de-Souza A, Nunes de Souza RL, Pelá IR, Graeff FG (March 1998). "Involvement of the midbrain periaqueductal gray 5-HT1A receptors in social conflict induced analgesia in mice". European Journal of Pharmacology. 345 (3): 253–6. doi:10.1016/s0014-2999(98)00018-1. PMID 9592023.
  5. ↑ Nelson DL (December 1991). "Structure-activity relationships at 5-HT1A receptors: binding profiles and intrinsic activity". Pharmacol Biochem Behav. 40 (4): 1041–1051. doi:10.1016/0091-3057(91)90124-k. PMID 1816558.
  6. ↑ Taylor EW, Nikam S, Weck B, Martin A, Nelson D (October 1987). "Relative selectivity of some conformationally constrained tryptamine analogs at 5-HT1, 5-HT1A and 5-HT2 recognition sites" (PDF). Life Sci. 41 (16): 1961–1969. doi:10.1016/0024-3205(87)90749-1. PMID 3657392. Archived from the original on 2019-07-21. Retrieved 2025-03-24.{{cite journal}}: CS1 maint: bot: original URL status unknown (link)
This article is issued from WikiProjectMed. The text is available under Creative Commons Attribution-ShareAlike License unless otherwise noted. Additional terms may apply for the media files.