5-MeO-MPMI

5-MeO-MPMI
Clinical data
Other names5-Methoxy-N-methyl-(α,N-trimethylene)tryptamine; CP-108509; CP108509
Drug classSerotonergic psychedelic; Hallucinogen
ATC code
  • None
Legal status
Legal status
  • DE: NpSG (Industrial and scientific use only)
  • UK: Class A
Identifiers
IUPAC name
  • 5-methoxy-3-{[(2R)-1-methylpyrrolidin-2-yl]methyl}-1H-indole
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC15H20N2O
Molar mass244.338 g·mol−1
3D model (JSmol)
SMILES
  • CN1CCC[C@@H]1CC2=CNC3=C2C=C(C=C3)OC
InChI
  • InChI=1S/C15H20N2O/c1-17-7-3-4-12(17)8-11-10-16-15-6-5-13(18-2)9-14(11)15/h5-6,9-10,12,16H,3-4,7-8H2,1-2H3/t12-/m1/s1 checkY
  • Key:MKEGUJPBCIXABO-GFCCVEGCSA-N checkY
 ☒NcheckY (what is this?)  (verify)

5-MeO-MPMI (developmental code name CP-108509), also known as 5-methoxy-N-methyl-(α,N-trimethylene)tryptamine, is a psychedelic drug of the pyrrolidinylmethylindole and cyclized tryptamine families.[1]

Interactions

Pharmacology

Pharmacodynamics

5-MeO-MPMI produces psychedelic-appropriate responding in animal tests, with similar potency to DOI.[1] It has two enantiomers, with only the (R)-enantiomer being active.[1]

History

5-MeO-MPMI was first developed by the team led by J. E. Macor and colleagues in 1992.[2] It was subsequently investigated by the team led by David E. Nichols from Purdue University in the late 1990s.[1]

See also

References

  1. 1 2 3 4 Gerasimov M, Marona-Lewicka D, Kurrasch-Orbaugh DM, Qandil AM, Nichols DE (1999). "Further studies on oxygenated tryptamines with LSD-like activity incorporating a chiral pyrrolidine moiety into the side chain". Journal of Medicinal Chemistry. 42 (20): 4257–4263. CiteSeerX 10.1.1.690.4941. doi:10.1021/jm990325u. PMID 10514296.
  2. ↑ Macor JE, Blake J, Fox CB, Johnson C, Koe BK, Lebel LA, Morrone JM, Ryan K, Schmidt AW, Schulz DW, et al. (1992). "Synthesis and serotonergic pharmacology of the enantiomers of 3-[(N-methylpyrrolidin-2-yl)methyl]-5-methoxy-1H-indole: discovery of stereogenic differentiation in the aminoethyl side chain of the neurotransmitter serotonin". Journal of Medicinal Chemistry. 35 (23): 4503–4505. doi:10.1021/jm00101a032. PMID 1447752.
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