Dipyanone

Dipyanone
Identifiers
	IUPAC name 4,4-diphenyl-6-(1-pyrrolidinyl)-heptan-3-one;
CAS Number	60996-94-3 ;
PubChem CID	57483648;
ChemSpider	128910076;
UNII	P8UN8D5PUN;
CompTox Dashboard (EPA)	DTXSID401336888 ;
Chemical and physical data
Formula	C23H29NO
Molar mass	335.491 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCC(=O)C(CC(C)N1CCCC1)(c1ccccc1)c1ccccc1;
	InChI InChI=1S/C23H29NO/c1-3-22(25)23(20-12-6-4-7-13-20,21-14-8-5-9-15-21)18-19(2)24-16-10-11-17-24/h4-9,12-15,19H,3,10-11,16-18H2,1-2H3; Key:LJIUPFDRFKFNJE-UHFFFAOYSA-N;

Dipyanone is an opioid analgesic which has been sold as a designer drug, first identified in Germany in 2021.^[1]^[2] It is closely related to medically used drugs such as methadone, dipipanone and phenadoxone, but is slightly less potent.^[3]^[4]^[5]

References

↑ European Monitoring Centre for Drugs and Drug Addiction. (June 2022). New psychoactive substances: 25 years of early warning and response in Europe. An update from the EU Early Warning System (PDF). European Monitoring Centre for Drugs and Drug Addiction. doi:10.2810/882318 (inactive 12 July 2025). ISBN 978-92-9497-737-3.{{cite book}}: CS1 maint: DOI inactive as of July 2025 (link)
↑ Vandeputte MM, Walton SE, Shuda SA, Papsun DM, Krotulski AJ, Stove CP. Detection, chemical analysis, and pharmacological characterization of dipyanone and other new synthetic opioids related to prescription drugs. Anal Bioanal Chem. 2023 Sep;415(21):5165-5180. doi:10.1007/s00216-023-04722-7 PMID 37173408
↑ Ofner P, Walton E (1950). "444. Search for new analgesics. Part IV. Variations in the basic side-chain of amidone". Journal of the Chemical Society (Resumed): 2158. doi:10.1039/JR9500002158.
↑ Lenz GR, Evans SM, Walters DE, Hopfinger AJ (1986). Opiates. Academic Press. pp. 406–407. ISBN 978-0-12-443830-9.
↑ Berardinelli D, Kutzler J, Taoussi O, Zaami S, Pichini S, Basile G, Busardò FP, Auwärter V, Carlier J. Dipyanone, a new methadone-like synthetic opioid: In vitro and in vivo human metabolism and pharmacological profiling. Arch Toxicol. 2025 Jun;99(6):2339-2353. doi:10.1007/s00204-025-04023-1 PMID 40295323