Transcription factors and intracellular receptors |
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(1) Basic domains |
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| (1.1) Basic leucine zipper (bZIP) |
- Activating transcription factor
- AP-1
- BACH
- BATF
- BLZF1
- C/EBP
- CREB
- CREM
- DBP
- DDIT3
- GABPA
- GCN4
- HLF
- MAF
- NFE
- NFIL3
- NRL
- NRF
- XBP1
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| (1.2) Basic helix-loop-helix (bHLH) | | Group A |
- AS-C
- ATOH1
- HAND
- MESP2
- Myogenic regulatory factors
- NeuroD
- Neurogenins
- OLIG
- Paraxis
- SLC
- Twist
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| Group B | |
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Group C bHLH-PAS |
- AhR
- AHRR
- ARNT
- CLOCK
- HIF
- NPAS
- PER
- SIM
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| Group D | |
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| Group E | |
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Group F bHLH-COE | |
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| (1.3) bHLH-ZIP |
- AP-4
- MAX
- MITF
- MNT
- MLX
- MLXIPL
- MXI1
- Myc
- SREBP
- USF1
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| (1.4) NF-1 | |
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| (1.5) RF-X | |
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| (1.6) Basic helix-span-helix (bHSH) | |
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(2) Zinc finger DNA-binding domains |
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| (2.1) Nuclear receptor (Cys4) | | subfamily 1 |
- Thyroid hormone
- CAR
- FXR
- LXR
- PPAR
- PXR
- RAR
- ROR
- Rev-ErbA
- VDR
|
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| subfamily 2 |
- COUP-TF
- Ear-2
- HNF4
- PNR
- RXR
- Testicular receptor
- TLX
|
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| subfamily 3 |
- Steroid hormone
- Androgen
- Estrogen
- Glucocorticoid
- Mineralocorticoid
- Progesterone
- Estrogen related
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| subfamily 4 | |
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| subfamily 5 | |
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| subfamily 6 | |
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| subfamily 0 | |
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| (2.2) Other Cys4 | |
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| (2.3) Cys2His2 | |
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| (2.4) Cys6 | |
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| (2.5) Alternating composition |
- AIRE
- DIDO1
- GRLF1
- ING
- JARID
- JMJD1B
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| (2.6) WRKY | |
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(3) Helix-turn-helix domains |
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| (3.1) Homeodomain | |
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| (3.2) Paired box |
- PAX
- PRRX
- PROP1
- PHOX
- RAX
- SHOX
- SHOX2
- VSX1
- VSX2
- Bicoid
|
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| (3.3) Fork head / winged helix |
- E2F
- FOX proteins
- A1
- A2
- A3
- B1
- B2
- C1
- C2
- D1
- D2
- D3
- D4
- D4L1
- D4L3
- D4L4
- D4L5
- D4L6
- E1
- E3
- F1
- F2
- G1
- H1
- I1
- I2
- I3
- J1
- J2
- J3
- K1
- K2
- L1
- L2
- M1
- N1
- N2
- N3
- N4
- O1
- O3
- O4
- O6
- P1
- P2
- P3
- P4
- Q1
- R1
- R2
- S1
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| (3.4) Heat shock factors | |
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| (3.5) Tryptophan clusters |
- ELF
- EHF
- ELK
- ERF
- ETS
- ETV
- FLI1
- Interferon regulatory factors
- MYB
- MYBL2
|
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| (3.6) TEA domain |
- transcriptional enhancer factor
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(4) β-Scaffold factors with minor groove contacts |
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| (4.1) Rel homology region |
- NF-κB
- NFKB1
- NFKB2
- REL
- RELA
- RELB
- NFAT
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| (4.2) STAT | |
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| (4.3) p53-like |
- p53 p63 p73 family
- TBX
- 1
- 2
- 3
- 5
- 19
- 21
- 22
- TBR1
- TBR2
- TFT
- MYRF
|
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| (4.4) MADS box | |
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| (4.6) TATA-binding proteins | |
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| (4.7) High-mobility group |
- BBX
- HMGB
- HMGN
- HNF
- SOX
- 1
- 2
- 3
- 4
- 5
- 6
- 8
- 9
- 10
- 11
- 12
- 13
- 14
- 15
- 17
- 18
- 21
- SRY
- SSRP1
- TCF/LEF
- TOX
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| (4.9) Grainyhead | |
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| (4.10) Cold-shock domain | |
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| (4.11) Runt |
- CBF
- CBFA2T2
- CBFA2T3
- RUNX1
- RUNX2
- RUNX3
- RUNX1T1
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(0) Other transcription factors |
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| (0.2) HMGI(Y) | |
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| (0.3) Pocket domain | |
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| (0.5) AP-2/EREBP-related factors | |
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| (0.6) Miscellaneous | |
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see also transcription factor/coregulator deficiencies |