New methylene blue

New methylene blue
Identifiers
CAS Number
3D model (JSmol)
ChemSpider
ECHA InfoCard 100.026.833
PubChem CID
UNII
InChI
  • InChI=1S/C18H22N3S.ClH/c1-5-19-13-9-17-15(7-11(13)3)21-16-8-12(4)14(20–6–2)10-18(16)22-17;/h7-10,19-20H,5-6H2,1-4H3;1H/q+1;/p-1 checkY
    Key: NZYCYASKVWSANA-UHFFFAOYSA-M checkY
  • InChI=1/C18H22N3S.ClH/c1-5-19-13-9-17-15(7-11(13)3)21-16-8-12(4)14(20–6–2)10-18(16)22-17;/h7-10,19-20H,5-6H2,1-4H3;1H/q+1;/p-1
    Key: NZYCYASKVWSANA-REWHXWOFAR
SMILES
  • [Cl-].Cc1cc2nc3cc(C)c(cc3[s+]c2cc1NCC)NCC
Properties
Chemical formula
 C18H22N3S:SCl ZnCl2
Molar mass 484.22 g/mol
Melting point 239 °C (462 °F; 512 K)
Boiling point Decomposes
Hazards
GHS labelling:
Pictograms
 GHS07: Exclamation mark
Signal word
 Warning
Hazard statements
 H302, H312, H332
Precautionary statements
 P261, P264, P270, P271, P280, P301+P317, P302+P352, P304+P340, P317, P321, P330, P362+P364, P501
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

New methylene blue (also NMB, and Basic Blue 24) is an organic compound of the thiazine class of heterocycles. It is used as a stain and as an antimicrobial agent. It is classified as an azine dye, and the chromophore is a cation, the anion is often unspecified.[1]

New Methylene Blue contains the word "New" in its name to differentiate the effectiveness of staining, between its predecessor methylene blue, the chemical structure of methylene blue, and the colors between the two.[2]

Applications

NMB is a staining agent used in diagnostic cytopathology and histopathology, typically for staining immature red blood cells. It is a supravital stain.[3] It is closely related to methylene blue, an older stain in wide use.

Safety

New methylene blue is toxic. Skin contact or inhalation should be avoided.

See also

References

  1. ↑ Vennerstrom, Jonathan L.; Makler, Michael T.; Angerhofer, Cidy K.; Williams, Jean A. "Antimalarial dyes revisited: xanthenes, azines, oxazines, and thiazine" Antimicrobial Agents and Chemotherapy (1995), 39(12), 2671–7. doi:10.1128/AAC.39.12.2671.
  2. ↑ "New Methylene Blue as A Reticulocyte Stain". George Brecher. 1 Sep 1949.
  3. ↑ "Reticulocyte Count" (PDF). Prentice-Hall. Archived from the original (PDF) on 2018-11-23. Retrieved 2012-03-25.
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