Macacine gammaherpesvirus 4

Lymphocryptovirus macacinegamma4
Virus classification Edit this classification
(unranked): Virus
Realm: Duplodnaviria
Kingdom: Heunggongvirae
Phylum: Peploviricota
Class: Herviviricetes
Order: Herpesvirales
Family: Orthoherpesviridae
Genus: Lymphocryptovirus
Species:
Lymphocryptovirus macacinegamma4
Synonyms
  • Rhesus lymphocryptovirus
  • Cercopithecine herpesvirus 15
  • Macacine gammaherpesvirus 4
  • Rhesus HHV-4-like virus
  • Rhesus Epstein Barr virus
  • Rhesus EBV-like herpesvirus

Macacine gammaherpesvirus 4 (McHV-4), commonly known as rhesus lymphocryptovirus (RLV), is a species of virus in the genus Lymphocryptovirus, subfamily Gammaherpesvirinae, family Herpesviridae, and order Herpesvirales.[1][2]

In nature, RLV infects rhesus macaques (Macaca mulatta).

Comparison with Epstein-Barr virus

Its genetic structure has been fully sequenced and found to be highly homologous with that of Epstein-Barr virus (EBV), at 65%. The structural proteins are highly conserved, while genes expressed during Human gammaherpesvirus 4 latent infection are much less well conserved. Even in cases where genes have low homology, the RLV infection genes are functionally interchangeable with EBV genes.[3]

RLV infection in rhesus monkeys resembles EBV infection in humans in several respects:

These features make the rhesus lymphocryptovirus potentially useful for studying the pathogenesis, prevention, and treatment of EBV infection and associated oncogenesis.[4]

References

Wikispecies has information related to Macacine gammaherpesvirus 4.
  1. ↑ "ICTV Master Species List 2018b.v2". International Committee on Taxonomy of Viruses (ICTV). Archived from the original on March 30, 2019. Retrieved 19 June 2019.
  2. ↑ "History of the taxon: Species: Lymphocryptovirus macacinegamma4 (2023 Release, MSL #39)". ictv.global. International Committee on Taxonomy of Viruses. Retrieved 30 January 2025.
  3. ↑ Rivailler P, Jiang H, Cho YG, Quink C, Wang F (2002). "Complete nucleotide sequence of the rhesus lymphocryptovirus: genetic validation for an Epstein-Barr virus animal model". J. Virol. 76 (1): 421–6. doi:10.1128/jvi.76.1.421-426.2002. PMC 135707. PMID 11739708.
  4. ↑ Amir Moghaddam; Michael Rosenzweig; David Lee-Parritz; Bethany Annis; R. Paul Johnson; Fred Wang (1997). "An Animal Model for Acute and Persistent Epstein-Barr Virus Infection". Science. 276 (5321): 2030–2033. doi:10.1126/science.276.5321.2030. PMID 9197263.
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