Luliconazole

Luliconazole
Names
Trade namesLuzu, Luzarn, Lulicon, others
IUPAC name
  • (2E)-[(4R)-4-(2,4-Dichlorophenyl)-1,3-dithiolan-2-ylidene](1H-imidazol-1-yl)acetonitrile
Clinical data
Drug classAntifungal (imidazole)[1]
Main usesAthlete's foot, jock itch, ringworm[2]
Side effectsItchiness, pain[1]
Routes of
use
Topical
External links
AHFS/Drugs.comMonograph
Legal
Legal status
  • In general: ℞ (Prescription only)
Pharmacokinetics
Protein binding>99%[3]
Chemical and physical data
FormulaC14H9Cl2N3S2
Molar mass354.27 g·mol−1
3D model (JSmol)
SMILES
  • C1[C@H](S/C(=C(\C#N)/N2C=CN=C2)/S1)C3=C(C=C(C=C3)Cl)Cl
InChI
  • InChI=1S/C14H9Cl2N3S2/c15-9-1-2-10(11(16)5-9)13-7-20-14(21-13)12(6-17)19-4-3-18-8-19/h1-5,8,13H,7H2/b14-12+/t13-/m0/s1
  • Key:YTAOBBFIOAEMLL-REQDGWNSSA-N

Luliconazole, sold under the brand name Luzu among others, is a medication used to treat athlete's foot, jock itch, and ringworm.[2] It is applied to the area affected.[2]

Common side effects include itchiness and pain.[1] Other side effects may include contact dermatitis.[1] Safety in pregnancy and breastfeeding is unclear.[2] It is in the imidazole family of medications.[1]

Luliconazole was approved for medical use in the United States in 2013.[2] In the United States it costs about 490 USD for a 60 gram tube of cream as of 2021.[4]

Medical uses

Spectrum of activity

This includes dermatophytes such as Trichophyton rubrum and Epidermophyton floccosum.[3]

Dosage

It is used once per day for 1 to 2 weeks.[2] It comes as a 1% cream.[2]

References

  1. 1.0 1.1 1.2 1.3 1.4 "Luliconazole Monograph for Professionals". Drugs.com. Archived from the original on 27 October 2021. Retrieved 24 November 2021.
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 "DailyMed - LULICONAZOLE cream". dailymed.nlm.nih.gov. Archived from the original on 11 December 2021. Retrieved 24 November 2021.
  3. 3.0 3.1 "LUZU (luliconazole) Cream, 1%. Full Prescribing Information" (PDF). Valeant Pharmaceuticals North America LLC. Archived (PDF) from the original on 4 March 2016. Retrieved 1 October 2015.
  4. "Luzu Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 29 September 2016. Retrieved 24 November 2021.

External links

Identifiers: