Escherichia coli Nissle 1917
| Escherichia coli strain Nissle 1917 | |
|---|---|
Scientific classification | |
| Domain: | Bacteria |
| Kingdom: | Pseudomonadati |
| Phylum: | Pseudomonadota |
| Class: | Gammaproteobacteria |
| Order: | Enterobacterales |
| Family: | Enterobacteriaceae |
| Genus: | Escherichia |
| Species: | E. coli |
| Strain: | E. c. strain Nissle 1917 |
| Trionomial name | |
Escherichia coli strain Nissle 1917 | |
Escherichia coli Nissle 1917 is a strain of Escherichia coli that was isolated from the feces of a German soldier in 1917 by the German researcher Alfred Nissle. Nissle isolated the bacteria from a soldier that appeared to be unaffected by Shigella bacteria. Nissle suspected this soldier to carry an antagonistically strong E. coli strain that might have protected him from catching dysentery. In fact, this soldier carried an E. coli strain (later named strain Nissle 1917) that in laboratory tests showed strong antagonistic activity against pathogenic gut bacteria.Since that time it has been widely studied as a probiotic and several marketed probiotics include it and naturally colonizes the human intestines and has positive probiotic properties.[1] In one small study, 4 out of 7 people who took it daily for a week had detectable amounts in their feces.[2] The exact reasons for colonization are unknown. It is known that the F1C fimbriae are important for colonization.[3]
References
- ↑ Sonnenborn, U (October 2016). "Escherichia coli strain Nissle 1917-from bench to bedside and back: history of a special Escherichia coli strain with probiotic properties". FEMS Microbiology Letters. 363 (19) fnw212. doi:10.1093/femsle/fnw212. PMID 27619890.
- ↑ Prilassnig, M; Wenisch, C; Daxboeck, F; Feierl, G (2007). "Are probiotics detectable in human feces after oral uptake by healthy volunteers?". Wien Klin Wochenschr. 119: 456–462. doi:10.1007/s00508-007-0808-1. PMID 1772176.
- ↑ Lasaro, MA; Salinger, N; Zhang, J; Wang, Y; Zhong, Z; Goulian, M; Zhu, J (January 2009). "F1C fimbriae play an important role in biofilm formation and intestinal colonization by the Escherichia coli commensal strain Nissle 1917". Applied and Environmental Microbiology. 75 (1): 246–51. Bibcode:2009ApEnM..75..246L. doi:10.1128/AEM.01144-08. PMC 2612203. PMID 18997018.