Xi Ophiuchi
Xi Ophiuchi was a binary star system in the Alpha Quadrant. (PIC: "Disengage")
In 2401, this system's position was labeled on a star chart used by Captain William T. Riker during his attempt at finding the last known location of the SS Eleos XII. (PIC: "The Next Generation")
In 3191, this system's location was labeled on a star chart. (DIS: "Red Directive")
This star system was only mentioned in writing.
The location of this star system was seen on the bridge of the SS Eleos XII on what appears to be an updated chart from Star Trek: Star Charts. Dave Blass published pictures of the set on his website.