Crusher family
The Crusher family consisted of Jack R. Crusher, his parents, his wife Beverly Crusher (née Howard), their son Wesley Crusher, and her son with Jean-Luc Picard, Jack Crusher.
During a holo-recording Jack made when Wesley was only 10 weeks old, he mentioned seeing his father and mother in the child's face. (TNG: "Family")
Picard was a close friend of the Crusher family, something Rear Admiral Brand was aware of when she personally informed Picard that Cadet Wesley Crusher had been involved in an accident while training at Starfleet Academy in a flight trainer in 2368. (TNG: "The First Duty")
Later, Picard's connection to the Crusher family became biological when he had a son with Beverly, Jack Crusher, who was named after Jack. (Star Trek: Picard)