Respiratory syncytial virus G protein

Major surface glycoprotein G
Identifiers
SymbolGlycoprotein_G
PfamPF00802
InterProIPR000925
SCOP21brv / SCOPe / SUPFAM
Major surface glycoprotein G
Identifiers
OrganismHuman respiratory syncytial virus A (strain A2)
SymbolG
PDB5WN9
UniProtP03423

Respiratory syncytial virus G protein is a glycoprotein produced by respiratory syncytial virus.[1][2][3]

Some features of the G protein suggest it could be important to respiratory syncytial virus vaccine or antiviral drug target design. [4][5]

Three schematics represent disease pathogenesis associated 1st schematic with no vaccine ,2nd schematic an F protein vaccine , 3rd schematic an F + G protein vaccine[6]

References

  1. ↑ Harcourt J, Alvarez R, Jones LP, Henderson C, Anderson LJ, Tripp RA (February 2006). "Respiratory syncytial virus G protein and G protein CX3C motif adversely affect CX3CR1+ T cell responses". Journal of Immunology. 176 (3): 1600–8. doi:10.4049/jimmunol.176.3.1600. PMID 16424189.
  2. ↑ Li XQ, Fu ZF, Alvarez R, Henderson C, Tripp RA (January 2006). "Respiratory syncytial virus (RSV) infects neuronal cells and processes that innervate the lung by a process involving RSV G protein". Journal of Virology. 80 (1): 537–40. doi:10.1128/JVI.80.1.537-540.2006. PMC 1317531. PMID 16352577.
  3. ↑ Zlateva KT, Lemey P, Moës E, Vandamme AM, Van Ranst M (July 2005). "Genetic variability and molecular evolution of the human respiratory syncytial virus subgroup B attachment G protein". Journal of Virology. 79 (14): 9157–67. doi:10.1128/JVI.79.14.9157-9167.2005. PMC 1168771. PMID 15994810.
  4. ↑ Li X, Sambhara S, Li CX, Ettorre L, Switzer I, Cates G, James O, Parrington M, Oomen R, Du RP, Klein M (March 2000). "Plasmid DNA encoding the respiratory syncytial virus G protein is a promising vaccine candidate". Virology. 269 (1): 54–65. doi:10.1006/viro.2000.0186. PMID 10725198.
  5. ↑ Anderson LJ, Jadhao SJ, Paden CR, Tong S (July 2021). "Functional Features of the Respiratory Syncytial Virus G Protein". Viruses. 13 (7): 1214. doi:10.3390/v13071214. PMC 8310105. PMID 34372490.
  6. ↑ Boyoglu-Barnum S, Chirkova T, Anderson LJ (2019). "Biology of Infection and Disease Pathogenesis to Guide RSV Vaccine Development". Frontiers in Immunology. 10. doi:10.3389/fimmu.2019.01675/full. ISSN 1664-3224.{{cite journal}}: CS1 maint: unflagged free DOI (link)

Further reading

  • McLellan JS, Ray WC, Peeples ME (2013). "Structure and Function of Respiratory Syncytial Virus Surface Glycoproteins". Challenges and Opportunities for Respiratory Syncytial Virus Vaccines. Current Topics in Microbiology and Immunology. Vol. 372. pp. 83–104. doi:10.1007/978-3-642-38919-1_4. ISBN 978-3-642-38918-4. PMC 4211642. PMID 24362685.
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