Darier sign
| Darier sign | |
|---|---|
 | |
| Mastocytosis: Darier's sign | |
 | |
| Specialty | Dermatology |
| Named after | Ferdinand-Jean Darier[1] |
Darier sign is a change observed after stroking lesions on the skin of a person with urticaria pigmentosa.[2]
In general, the skin becomes swollen, itchy and red.[3] This is a result of compression of mast cells, which are hyperactive in these diseases. These mast cells release inflammatory granules which contain histamine. It is the histamine which is responsible for the response seen after rubbing the lesional skin.
The sign is named for the French dermatologist Ferdinand-Jean Darier (1856–1938) who first described it.[1]
Additional images
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Stroking the skin leads to a localised subcutaneous anaphylactoid reaction with mast cell degranulation and urticarial rash
See also
References
- ↑ 1.0 1.1 Crissey, John Thorne; Parish, Lawrence C.; Holubar, Karl (2013). "Late nineteenth century French dermatology". Historical Atlas of Dermatology and Dermatologists. CRC Press. p. 75. ISBN 978-1-84184-864-8. Archived from the original on 2023-06-30. Retrieved 2023-05-20.
- ↑ Mosby's Pocket Dictionary of Medicine, Nursing & Health Professions (Ninth ed.). St. Louis, Missouri: Elsevier. 2024. p. 343. ISBN 978-0-323-83291-5. Archived from the original on 2023-06-30. Retrieved 2023-05-20.
- ↑ Tiano, Rasa; Krase, Ifat Z.; Sacco, Keith (April 2023). "Updates in diagnosis and management of paediatric mastocytosis". Current Opinion in Allergy and Clinical Immunology. 23 (2): 158. doi:10.1097/ACI.0000000000000869. ISSN 1528-4050. PMID 36730855. Archived from the original on 29 December 2023. Retrieved 19 May 2025.